Instantly calculate creatinine clearance using the Cockcroft-Gault formula.
Scroll Down to CalculateEnter patient information to calculate creatinine clearance using the Cockcroft-Gault equation.
Disclaimer: This tool is for informational purposes only and not a substitute for professional medical advice. Always consult with a healthcare provider for medical decisions.
Creatinine clearance (CrCl) is a clinical measurement that estimates how efficiently the kidneys filter creatinine from the blood. It serves as an important indicator of kidney function and is commonly used to assess renal health, adjust medication dosages, and monitor kidney disease progression.
The Cockcroft-Gault equation is one of the most widely used methods to estimate creatinine clearance without requiring a 24-hour urine collection. It takes into account a person's age, weight, gender, and serum creatinine level to provide an estimate of the glomerular filtration rate (GFR).
For Males:
CrCl (mL/min) = (140 - age) × weight (kg) × 1.23 / serum creatinine (μmol/L)
CrCl (mL/min) = (140 - age) × weight (kg) / (72 × serum creatinine (mg/dL))
For Females:
CrCl (mL/min) = (140 - age) × weight (kg) × 1.04 / serum creatinine (μmol/L)
CrCl (mL/min) = (140 - age) × weight (kg) × 0.85 / (72 × serum creatinine (mg/dL))
Input the patient's age, gender, weight, and serum creatinine level into the calculator.
Our calculator automatically applies the Cockcroft-Gault formula to the provided data.
View the calculated creatinine clearance value in mL/min along with an interpretation of the result.
1. Cockcroft, D.W. and M.H. Gault. Prediction of creatinine clearance from serum creatinine. Nephron. 1976. 16(1):31-41
2. Josef Coresh , L A Stevens. Kidney function estimating equations: where do we stand? Curr Opin Nephrol Hypertens. May 2006;15(3): 276-84
3. National Kidney Foundation: GFR (Glomerular Filtration Rate)
4. Levey AS, Stevens LA. Estimating GFR using the CKD Epidemiology Collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. Am J Kidney Dis. Apr 2010;55(4):622-627
5. Inker, AS. Frequently Asked Questions About GFR Estimates. New York: The National Kidney Foundation; 2011
The CrCl (Creatinine Clearance) Calculator provides a quick and accurate estimation of kidney filtration function using the Cockcroft-Gault formula. It helps assess renal health, adjust drug dosages, and monitor kidney disease progression.
This tool is especially useful in clinical settings where real-time kidney function estimation is critical. It takes into account age, weight, sex, serum creatinine, and optionally height to provide a more precise BMI-adjusted estimate.
Understanding your Creatinine Clearance (CrCl) or Glomerular Filtration Rate (GFR) can help determine stages of Chronic Kidney Disease (CKD). The table below shows the classification of kidney function based on CrCl or GFR values.
| Category | CrCl or GFR (mL/min) | Interpretation |
|---|---|---|
| Normal or High | ≥90 | Normal kidney function (CKD Stage 1 if other evidence of kidney damage exists) |
| Mildly Decreased | 60–89 | Mild kidney damage (CKD Stage 2) |
| Moderately Decreased | 30–59 | Moderate decrease in kidney function (CKD Stage 3) |
| Severely Decreased | 15–29 | Severe decrease in kidney function (CKD Stage 4) |
| Kidney Failure | <15 | Kidney failure (CKD Stage 5); may require dialysis or transplantation |
Several formulas are used to estimate kidney function. Here's how the Cockcroft-Gault formula compares with others:
Each formula serves different purposes. Cockcroft-Gault remains the standard in medication dosing, while MDRD and CKD-EPI are often used for diagnosing and staging chronic kidney disease.
Creatinine clearance is crucial in various clinical scenarios:
Understanding CrCl values can significantly improve patient safety and treatment outcomes, especially in nephrology and internal medicine.
Normal creatinine clearance values typically range from 90 to 140 mL/min for men and 80 to 125 mL/min for women. Values below 60 mL/min may indicate kidney disease, while values below 15 mL/min often indicate kidney failure requiring dialysis or transplantation.
No, the Cockcroft-Gault formula was developed for adults and is not validated for use in children. For pediatric patients, other formulas such as the Schwartz equation are more appropriate for estimating kidney function.
No, this calculator is intended as an educational tool and should not be used as the sole basis for diagnosis or treatment decisions. Always consult with a healthcare professional for proper interpretation of results and medical advice.
You can enter weight in either kilograms (kg) or pounds (lbs), and serum creatinine in either mg/dL or µmol/L. The calculator will automatically convert units as needed for the calculation.
The frequency of measurement depends on the individual's health status. For patients with chronic kidney disease, it may be monitored every 3-12 months. For those on medications that affect kidney function or are nephrotoxic, more frequent monitoring may be necessary.
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